Revealing cancer glycome drivers using CRISPR activation screens
investigate the genetic determinants underlying cancer-associated glycome remodeling. Using genome-wide CRISPR-based approaches, they identified regulators of cell surface glycosylation. Specifically, genetic networks are discovered that upregulate cancer-related ligands of the sialic acid-binding immunomodulatory Siglecs.
Authors
- Matthew Scott Macauley (ORCID: https://orcid.org/0000-0003-4579-1048)
- Mathieu Decloquement
Institutions
- University of Alberta (CA)
Publication Details
- Journal
- Cell Genomics
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.xgen.2026.101215
- Primary Topic
- Cell Image Analysis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canada Research Chairs
- Alberta Innovates