Translational Modeling of Gut Microbiome‐Mediated Drug Metabolism: A Case Example of Sulfasalazine
, and AUC, respectively. Overall, this in vitro to in vivo translation and modeling framework provides valuable insights for quantitatively predicting the in vivo impact of gut microbiome-mediated drug metabolism.
Authors
- Lisa Cheng
- Sungjoon Cho (ORCID: https://orcid.org/0000-0003-1215-9759)
- Horace Rhee
- Miaoran Ning (ORCID: https://orcid.org/0000-0002-2949-4759)
- Jingwei Cai (ORCID: https://orcid.org/0000-0002-3626-3350)
- Dari Shalon (ORCID: https://orcid.org/0000-0003-2646-6215)
- Alexis Auster (ORCID: https://orcid.org/0000-0001-9638-7630)
- Bennett Kapili
- Mary Keir
Institutions
- University of British Columbia (CA)
- Gene Therapy Laboratory (FR)
- Pivot Bio (United States) (US)
- Sunesis (United States) (US)
Publication Details
- Journal
- CPT Pharmacometrics & Systems Pharmacology
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/psp4.70246
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00