Subjective and Objective Visual Quality Outcomes After KLEx vs KLEx Xtra: A 2-Year Prospective Randomized Trial

PURPOSE: To compare the 2-year refractive correction outcomes and subjective and objective visual quality between keratorefractive lenticule extraction (KLEx) and KLEx combined with corneal cross-linking (KLEx Xtra). METHODS: . Visual acuity and optical quality (objective and subjective) were assessed preoperatively and at 1, 6, 12, and 24 months postoperatively. RESULTS: < .05), but all metrics became comparable between the groups by 12 to 24 months, Early postoperative increases in HOAs in the KLEx Xtra group resolved by 6 months postoperatively. Subjective quality of vision scores showed no significant intergroup differences at 24 months, except for glare. CONCLUSIONS: KLEx Xtra enhances long-term refractive stability without detriment to visual quality, making it a viable option for patients with borderline risk profiles.

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Publication Details

Journal
Journal of Refractive Surgery
Published
2026-04-01
DOI
https://doi.org/10.3928/1081597x-20260112-09
Primary Topic
Corneal surgery and disorders
Type
article
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article

Subjective and Objective Visual Quality Outcomes After KLEx vs KLEx Xtra: A 2-Year Prospective Randomized Trial

Xianglian Li, Wangyuan Liu, Chenli Feng, Xiuyu Mao et al.
Journal of Refractive Surgery
Corneal surgery and disorders
article

Subjective and Objective Visual Quality Outcomes After KLEx vs KLEx Xtra: A 2-Year Prospective Randomized Trial

Xianglian Li, Wangyuan Liu, Chenli Feng, Xiuyu Mao, Qianhong Feng, Jiayue Yuan, Xueqi Lin, Xinran Li, Jinhui Dai, Jing Cong, Shichu Liu, Yingying Hu
article en

Abstract

PURPOSE: To compare the 2-year refractive correction outcomes and subjective and objective visual quality between keratorefractive lenticule extraction (KLEx) and KLEx combined with corneal cross-linking (KLEx Xtra). METHODS: . Visual acuity and optical quality (objective and subjective) were assessed preoperatively and at 1, 6, 12, and 24 months postoperatively. RESULTS: < .05), but all metrics became comparable between the groups by 12 to 24 months, Early postoperative increases in HOAs in the KLEx Xtra group resolved by 6 months postoperatively. Subjective quality of vision scores showed no significant intergroup differences at 24 months, except for glare. CONCLUSIONS: KLEx Xtra enhances long-term refractive stability without detriment to visual quality, making it a viable option for patients with borderline risk profiles.

Journal of Refractive SurgeryVol. 42(4)
Sun Yat-sen University (CN), Fudan University (CN), Zhongshan Hospital (CN), The First Affiliated Hospital, Sun Yat-sen University (CN)
No poverty
Openalex Percentile: Top 24%
Corneal surgery and disorders
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