Extended Transoral Resection of Anterior Commissure Tumors in a Canine Model: Impact on Laryngeal Framework, Glottis, and Vocal Function

Background and Objectives: Evaluate the feasibility and functional outcomes of extended transoral resection for anterior commissure (AC) tumors in canines, focusing on laryngeal framework, airway, and vocal function. Methods: Twelve dogs underwent endoscopic partial thyroid cartilage resection, randomized into: Group A (AC + adjacent cartilage), Group B (AC + left vocal cord anterior 1/3), Group C (AC + bilateral vocal cord anterior 1/3). Outcomes assessed included laryngoscopic healing, CT-measured laminal angle (LA) and glottal area (GA), weight, and GRBAS vocal scores. Results: = 0.008). Weight transiently decreased at day 7 but recovered by day 35. Conclusion: Extended transoral resection effectively removes AC lesions while preserving airway dimensions. However, extensive resection causes significant vocal dysfunction, highlighting the balance between oncologic radicality and function preservation. The potential LA-RMH correlation reveals the stabilizing characteristics of cartilaginous structures, offering preclinical insights for optimizing AC cancer surgery.