PLCH2 gene modifies the U-shaped association between environmental selenium exposure and blood total cholesterol: A gene-environment interaction study

<0.05) was observed between a haplotype of the PLCH2 and Se-U on TC: the U-shaped relationship was still observed in the PLCH2-ATCTCA haplotype carriers but not in the haplotype non-carriers. The results suggested PLCH2 gene can modify the U-shaped relationship between Se exposure and TC, which showed a new gene-environment interaction and will provide a new perspective on the relationship between Se exposure and TC.