Electromechanical Dynamics and Myogenic Responses in Cerebral Smooth Muscle Cells and Capillary Pericytes
sensitization with slow kinetics. The proposed cell model can form the basis for detailed multiscale and multicellular models that will examine physiological function at a single vessel or vascular network levels and investigate CBF control in health and in disease. Key points: sensitivity can alter contractile phenotype and electromechanical coupling along the arteriole to capillary continuum. The proposed model can form the basis for detailed multiscale and multicellular models that will investigate cerebral blood flow control in health and in disease.
Authors
- Fabrice Dabertrand (ORCID: https://orcid.org/0000-0003-2541-9185)
- Hannah R Ferris (ORCID: https://orcid.org/0000-0002-5675-5336)
- Nikolaos M. Tsoukias (ORCID: https://orcid.org/0000-0002-5164-9577)
- Nicholas R. Klug (ORCID: https://orcid.org/0000-0001-7540-0306)
- Mark T. Nelson
- Maria Sancho
Institutions
- University of Vermont (US)
- Universidad Complutense de Madrid (ES)
- Florida International University (US)
- University of Manchester (GB)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-06
- DOI
- https://doi.org/10.64898/2026.04.03.715998
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia e Innovación
- National Institutes of Health