EVALUATION OF CAMEL MILK BETA-CASEIN PROTEIN HYDROLYSATES FUNCTIONALITY AGAINST INDUCED DIABETES IN RATS

The current study was aimed to investigate the effect of beta-casein protein (β-CN) hydrolyzate, purified from Iraqi camel milk, on blood glucose levels, oral glucose tolerance test (OGTT), the levels of insulin, insulin-like growth factor 1 (IGF-1), level of liver enzymes [aspartate aminotransferase (AST), alanine aminotransferase (ALT)] and the lipid profile status of alloxan-induced diabetes rats. The results indicated that the β-CN protein hydrolysates at concentrations of 50 and 100 mg/kg showed a significant (p<0.05) reduction in the level of blood glucose during fasting and in (OGTT). However, there were, significant increasing (p<0.05) in the level of insulin, GF-1 and the level of high-density lipoproteins (HDL-C), meanwhile, a significant decreasing were observed on levels of liver enzymes AST and ALT, the levels of cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDL-C), and very low-density lipoproteins (VLDL-C). The findings of this study suggest camel milk β-CN protein hydrolysates could be as natural alternative product for the pharmacology medication in controlling the high blood glucose, increasing the concentration of insulin and IGF-1, in addition to controlliny the levels of lipids and liver enzymes at the normal limit.