Multi-Ion Channel Nanomedicines Targeting Zinc Transporter 1/ATPase Copper Transporters Disrupt Copper/Iron Homeostasis to Enhance Tumor Immunotherapy
-mediated disruption of cysteine (Cys) metabolism, compromises antioxidant defenses and triggers ferroptosis. This ionic dysregulation induces tumor cell death and promotes release of damage-associated molecular patterns (DAMPs) and mitochondrial DNA (mtDNA), activating immunogenic cell death (ICD) and the cGAS-STING pathway. Resultant dendritic cell (DC) maturation and T-cell activation link ion metabolic interference to systemic immune responses. This study establishes a multi-ion metabolic intervention strategy, advancing tumor immunotherapy paradigms.
Authors
- Yuting Li (ORCID: https://orcid.org/0009-0008-3848-8589)
- Guangyu Ma
- Kai You Wang (ORCID: https://orcid.org/0000-0002-6170-4744)
- Rongrong Sun (ORCID: https://orcid.org/0000-0001-7250-9971)
- Minghao Chao
- Yang Liu (ORCID: https://orcid.org/0000-0002-7734-5635)
- Fenglei Gao
- Jintao Guo
- Jiale Li
- Dehong Yu
- Xiang Li
Institutions
- Center for Drug Evaluation and Research (US)
- Xuzhou Medical College (CN)
- Affiliated Hospital of Xuzhou Medical College (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Lishui Central Hospital (CN)
- Second People’s Hospital of Huai’an (CN)
- Xuzhou Central Hospital (CN)
Publication Details
- Journal
- ACS Nano
- Published
- 2026-04-07
- DOI
- https://doi.org/10.1021/acsnano.6c00358
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Jiangsu Province