Effect of Acupuncture for Diminished Ovarian Reserve: A Randomized Sham-Controlled Trial

Objective: Acupuncture is a potential intervention for diminished ovarian reserve (DOR); however, the evidence remains limited. This single-center, randomized, sham-acupuncture controlled trial was conducted to evaluate the efficacy and safety of acupuncture in treating DOR. Methods: ), menstrual cycle length, and self-rating anxiety scale (SAS) scores. Results: , LH, and menstrual cycle length. A statistically significant between-group difference in SAS was noted exclusively at week 24. Treatment related adverse events were mild and infrequent. Conclusion: A 12-week of acupuncture significantly improved AFC in women with DOR compared to sham acupuncture. Further large-scale studies are warranted to confirm these findings and assess long-term outcomes.