Meta-Analytic Modeling to Define Decision Thresholds for Cerebrospinal Fluid Heparin-Binding Protein in Healthcare-Associated Ventriculitis and Meningitis

CSF HBP provides quantitatively defined rule-in and rule-out thresholds that meaningfully shift the post-test probability and may support antimicrobial decision-making in suspected HAVM. Prospective multicenter validation is warranted.

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Publication Details

Journal
Diagnostics
Published
2026-04-07
DOI
https://doi.org/10.3390/diagnostics16071110
Primary Topic
Cerebrospinal fluid and hydrocephalus
Type
article
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article

Meta-Analytic Modeling to Define Decision Thresholds for Cerebrospinal Fluid Heparin-Binding Protein in Healthcare-Associated Ventriculitis and Meningitis

Hsiang-Yi Hung, Yen-Ta Huang, Pei-Chun Lai, Po-An Su
Diagnostics
Cerebrospinal fluid and hydrocephalus
article

Meta-Analytic Modeling to Define Decision Thresholds for Cerebrospinal Fluid Heparin-Binding Protein in Healthcare-Associated Ventriculitis and Meningitis

Hsiang-Yi Hung, Yen-Ta Huang, Pei-Chun Lai, Po-An Su
article en

Abstract

CSF HBP provides quantitatively defined rule-in and rule-out thresholds that meaningfully shift the post-test probability and may support antimicrobial decision-making in suspected HAVM. Prospective multicenter validation is warranted.

DiagnosticsVol. 16(7)
Tzu Chi University (TW), Tzu Chi Foundation (TW), Hualien Tzu Chi Medical Center (TW), Chi Mei Medical Center (TW), National Cheng Kung University Hospital (TW)
Industry, innovation and infrastructure
Openalex Percentile: Top 29%
Cerebrospinal fluid and hydrocephalus
DOIOpen Access PDFOpenAlex
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Meta-Analytic Modeling to Define Decision Thresholds for Cerebrospinal Fluid Heparin-Binding Protein in Healthcare-Associated Ventriculitis and Meningitis — Hsiang-Yi Hung, Yen-Ta Huang, et al. · Diagnostics (2026) | TGRS Research Map | TGRS