Hierarchical Targeting of TREM2 <sup>+</sup> Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC
T cell infiltration, and inhibits over 70% of osteoclastogenesis, thereby achieving 79.5% suppression of osteolysis-mediated tumor progression. This strategy represents a novel approach for precise myeloid reprogramming in TNBC bone metastasis.
Authors
- Hangxiang Sun
- Zhenxuan Shao (ORCID: https://orcid.org/0000-0003-2294-4320)
- Fang Wang (ORCID: https://orcid.org/0000-0002-5971-2622)
- Zhisheng Li (ORCID: https://orcid.org/0000-0001-7811-8285)
- Haochen Mou (ORCID: https://orcid.org/0000-0001-6563-423X)
- Yi Xue (ORCID: https://orcid.org/0000-0003-2622-083X)
- Xiaoyan Yu (ORCID: https://orcid.org/0000-0002-0748-3522)
- Fanglu Chen
- Xiao Ma
- Zhaoming Ye
- Liang Chen
Institutions
- Zhejiang Energy Research Institute (CN)
- Zhejiang Lab (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Advanced Science
- Published
- 2026-04-07
- DOI
- https://doi.org/10.1002/advs.202517369
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Medical Science and Technology Project of Zhejiang Province
- Natural Science Foundation of Zhejiang Province