Discovery of Imidazo[2,1- <i>b</i> ][1,3,4]thiadiazole-Based MNK Inhibitors with Anti-inflammatory Efficacy via Dual Suppression of eIF4E Phosphorylation and NF-κB Signaling
suppressed eIF4E phosphorylation, NF-κB signaling, and macrophage polarization, thereby reducing pro-inflammatory cytokines and oxidative stress. These results suggest that MNK inhibition is a promising strategy for treating inflammatory diseases by targeting both inflammation and oxidative stress.
Authors
- Dianxi Zhang (ORCID: https://orcid.org/0000-0002-3541-6255)
- Ruijuan Yin
- Guanzhao Wu (ORCID: https://orcid.org/0000-0002-8170-7993)
- Lu Liu (ORCID: https://orcid.org/0009-0003-6744-9427)
- Tingting Qiu
- Hongwei Li
- Ziyi Sunyang
- Yuqiang Han
- Huiying Zhuang
Institutions
- Qingdao University (CN)
- Shandong University (CN)
- Qingdao National Laboratory for Marine Science and Technology (CN)
- Marine Biomedical Research Institute of Qingdao (CN)
- Qingdao Center of Resource Chemistry and New Materials (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-07
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c00577
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China