Comparison of HDO production from [2,3,4,6,6- <sup>2</sup> H <sub>5</sub> ]Glucose and [ <sup>2</sup> H <sub>7</sub> ]Glucose as a marker of Glucose metabolism
PURPOSE: . METHODS: metabolite levels were quantified using unlocalized and slice-selective localized spectra. RESULTS: study showed comparable glucose consumption and HDO production kinetics following tail-vein bolus administration of either metabolic contrast agent, while lactate was not detected in the brain. CONCLUSION: ]glucose for HDO-based DMI studies.
Authors
- Matthew E. Merritt (ORCID: https://orcid.org/0000-0003-4617-9651)
- Manoj Madheswaran (ORCID: https://orcid.org/0009-0005-9642-571X)
- James A. Bankson (ORCID: https://orcid.org/0000-0002-8574-154X)
- Vinay Malut (ORCID: https://orcid.org/0009-0005-1006-6323)
- Vikram D. Kodibagkar (ORCID: https://orcid.org/0000-0003-1933-8821)
- G. C. Sharma (ORCID: https://orcid.org/0009-0002-3832-0897)
- Sameer Naik
- Anna R. Nulk
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- University of Florida (US)
- Arizona State University (US)
- Florida College (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-07
- DOI
- https://doi.org/10.64898/2026.04.03.716329
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National High Magnetic Field Laboratory
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases
- Division of Materials Research
- High Magnetic Field Laboratory, Chinese Academy of Sciences