Disease Activity Trajectories During Pregnancy Predict Medically Indicated Complications in Women with Systemic Lupus Erythematosus

: Disease activity trajectories during pregnancy are strongly associated with clinically actionable pregnancy complications in women with SLE. Uncontrolled disease activity confers a markedly increased risk, while early disease flare followed by effective control does not. Trajectory-based assessment may improve risk stratification and support more individualized management during SLE pregnancies.