Pd-Catalyzed Buchwald–Hartwig Coupling of Imidazo[1,2-b]pyridazine with Aryl/Hetero Aryl Amines for the Synthesis of Functionalized Pyridazines
Abstract This work describes a practical method for coupling chloropyridazines and aryl/hetero aryl amines to get substituted aryl/hetroarylaminopyridazines. The newly developed condition tolerates a wide range of functional groups, including various heterocycles, electron-withdrawing/donating groups, and sensitive functional groups. This approach offers a convenient route to a range of secondary heterocyclic aminopyridazines that were otherwise challenging to synthesize.
Authors
- Anuradha Gupta (ORCID: https://orcid.org/0000-0002-4211-1441)
- Roshan Y. Nimje (ORCID: https://orcid.org/0000-0002-9438-5540)
- Kumargurubaran Kaliyaperumal
- Pandur Venkatesan Balaji (ORCID: https://orcid.org/0000-0003-0845-2469)
- Chiradeep Panja (ORCID: https://orcid.org/0000-0002-7564-8739)
- Amrita Roy (ORCID: https://orcid.org/0000-0003-2143-1013)
- Begur Vasanthkumar Varun (ORCID: https://orcid.org/0000-0003-2405-2406)
- Jeffin Joy A
- Ramakrishna Panchakharla
- Shabana Banu
- Arvind Mathur
- Santhosh Rao
Institutions
- Bristol-Myers Squibb (Germany) (DE)
- Bristol-Myers Squibb (Sweden) (SE)
- Bristol-Myers Squibb (Japan) (JP)
- Syngene International (India) (IN)
Publication Details
- Journal
- Synthesis
- Published
- 2026-04-07
- DOI
- https://doi.org/10.1055/a-2849-7091
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00