Therapeutic Modulation of Inflammatory Signaling via <i>Physalis Peruviana</i> ‐Derived Exosomes: A Targeted Effect on IKK/NFκB/STAT1
-challenged NIH3T3 fibroblasts, exosome treatment enhanced cell viability and upregulated endogenous antioxidant and mitochondrial defense markers, including CAT, SOD2, GPx4, and cytochrome c oxidase. These findings identify P. peruviana-derived exosomes as carotenoid-rich nanocarriers with anti-inflammatory and antioxidant properties, providing new mechanistic insight into the molecular actions of carotenoid-containing foods.
Authors
- Alberto José López Jiménez (ORCID: https://orcid.org/0000-0002-4992-631X)
- Susana López‐López (ORCID: https://orcid.org/0000-0001-9140-5123)
- Oussama Ahrazem (ORCID: https://orcid.org/0000-0001-9183-9319)
- Lucía Morote
- Lourdes Gómez‐Gómez
- Cristian Martínez Fajardo
Institutions
- University of Castilla-La Mancha (ES)
Publication Details
- Journal
- Molecular Nutrition & Food Research
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/mnfr.70458
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Universidad de Castilla-La Mancha
- Agencia Estatal de Investigación