<i>Mir147</i> Limits the Contribution of Non-Foamy Macrophages to Atherosclerosis
BACKGROUND: is upregulated by inflammatory stimuli in macrophages and in atherosclerotic lesions, suggesting a role in NFMs. METHODS: and control mice. The effect of the galectin-3 inhibitor GB1107 was studied using 4D live-plaque imaging. RESULTS: knockout effect in macrophages. CONCLUSIONS: levels might thus slow the expansion of the necrotic core and reduce atherothrombosis caused by NFM-induced endothelial damage.
Authors
- Alexander Bartelt (ORCID: https://orcid.org/0000-0001-7840-3991)
- Isabelle Baatsch
- Wolfgang Enard (ORCID: https://orcid.org/0000-0002-4056-0550)
- Yanyi Zhou
- Joerg Kumbrink
- Maliheh Nazari-Jahantigh (ORCID: https://orcid.org/0000-0002-1094-107X)
- Heya Na
- Philipp von Hundelshausen (ORCID: https://orcid.org/0000-0001-7474-9370)
- Eva Briem (ORCID: https://orcid.org/0009-0003-7506-3882)
- Carolin Jethwa
- Ya Li (ORCID: https://orcid.org/0000-0001-7246-2069)
- Mengyu Zhu (ORCID: https://orcid.org/0000-0003-2318-3666)
- Remco T.A. Megens
- Qiuxing Meng
- Shilun Li
- Sarah Polczer
- Yvonne Döring
- Andreas Schober
- Claudia Geissler
- Xinwei Li
- Tanya Guduru
- Khadijeh Taherdangkoo
- Nan Li
Institutions
- Maastricht University Medical Centre (NL)
- University Hospital of Bern (CH)
- Helmholtz Zentrum München (DE)
- Anna Needs Neuroblastoma Answers (US)
- German Centre for Cardiovascular Research (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Circulation
- Published
- 2026-04-07
- DOI
- https://doi.org/10.1161/circulationaha.125.077821
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00