Optimizing Health for Canadian Youth at Clinical High Risk for Psychosis: A Feasibility Study: Optimiser la santé des jeunes Canadiens présentant un risque clinique élevé de psychose : Une étude de faisabilité
= 26; 86.7% at 12 weeks), intervention fidelity, and ease of completing the clinical assessment schedule. Preliminary indicators of clinical efficacy were demonstrated by a decrease in psychiatric symptoms, improvement in resilience, and enhanced functioning.ConclusionsOHP-CHR is a promising psychosocial intervention co-designed by CHR youth. Our data support the acceptability of the intervention, the feasibility of conducting a confirmatory clinical trial, and preliminary evidence of efficacy in improving clinical and functional outcomes.Trial is registered at ClinicalTrials.gov NCT05757128.
Authors
- Muhammad Omair Husain (ORCID: https://orcid.org/0000-0002-8575-3364)
- Nicole Kozloff (ORCID: https://orcid.org/0000-0003-1389-1351)
- George Foussias (ORCID: https://orcid.org/0000-0001-6220-519X)
- David Jonathan Castle (ORCID: https://orcid.org/0000-0002-3075-1580)
- Lisa D. Hawke (ORCID: https://orcid.org/0000-0003-1108-9453)
- Michael Kiang (ORCID: https://orcid.org/0000-0003-1113-9211)
- Beatrice Todesco (ORCID: https://orcid.org/0000-0002-1313-7474)
- Yun Lu (ORCID: https://orcid.org/0009-0004-6504-4052)
- Gillian Strudwick
Institutions
- University of Tasmania (AU)
- Centre for Addiction and Mental Health (CA)
- Mental Health Research Institute (AU)
- University of Toronto (CA)
- Mental Health Australia (AU)
Publication Details
- Journal
- The Canadian Journal of Psychiatry
- Published
- 2026-04-07
- DOI
- https://doi.org/10.1177/07067437261436536
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Toronto
- Department of Psychiatry, University of Toronto
- Canadian Institutes of Health Research
- National Health and Medical Research Council