Coordination of Lipid Storage and Mobilization Pathways During Osteoblast Maturation in a 3D Human Bone Model
bands and modulation of protein-related Amide I-III signals, consistent with biochemical remodeling during maturation. Overall, the data indicate a coordinated transcriptional shift from lipid accumulation-associated pathways toward lipid mobilization during osteogenic progression in a 3D culture. This model provides a controlled experimental platform for investigating metabolic regulation during bone formation and for studying metabolic alterations associated with skeletal disorders.
Authors
- Dario Morganti (ORCID: https://orcid.org/0000-0003-1682-1092)
- Sabrina Conoci (ORCID: https://orcid.org/0000-0002-5874-7284)
- Domenico Trombetta (ORCID: https://orcid.org/0000-0003-4358-5224)
- Salvatore Guglielmino (ORCID: https://orcid.org/0000-0002-0401-6400)
- Caterina Faggio (ORCID: https://orcid.org/0000-0002-0066-2421)
- Barbara Fazio (ORCID: https://orcid.org/0000-0002-1947-1123)
- Antonella Smeriglio (ORCID: https://orcid.org/0000-0002-9756-304X)
- Emanuele Luigi Sciuto (ORCID: https://orcid.org/0000-0003-4972-9874)
- Maria Giovanna Rizzo (ORCID: https://orcid.org/0000-0001-6781-6387)
- Giorgia Cannatà
Institutions
- University of Messina (IT)
- Stazione Zoologica Anton Dohrn (IT)
- Institute for Microelectronics and Microsystems (IT)
- University of Bologna (IT)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2026-04-07
- DOI
- https://doi.org/10.3390/ijms27073325
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission