Modeling ALS in a dish: how organoids are transforming research
systems and the complex human nervous system, providing a unique framework to study ALS pathogenesis. This review provides a comprehensive overview of the various differentiation protocols, experimental strategies and key results obtained to date, with a primary focus on validating and benchmarking organoid models, while also highlighting their limitations, emerging clinical applications, translational potential, and opportunities for personalized therapeutic discovery.
Authors
- Ilaria Genovese (ORCID: https://orcid.org/0000-0002-1981-750X)
- Ersilia Fornetti (ORCID: https://orcid.org/0000-0002-6246-5351)
- Giancarlo Ruocco (ORCID: https://orcid.org/0000-0002-2762-9533)
- Gaia Galluzzi
Institutions
- Università di Camerino (IT)
- Italian Institute of Technology (IT)
- Saint Camillus International University of Health and Medical Sciences (IT)
- Center for Nano Science and Technology (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-04-07
- DOI
- https://doi.org/10.3389/fmed.2026.1792336
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Servier