Lycorine Derivative Inhibits SARS‐CoV‐2 Replication by Reducing −1 Programmed Ribosomal Frameshifting via Targeting ZAP
as a novel antiviral candidate that can combat SARS-CoV-2 and its variants by targeting ZAP to inhibit -1PRF. This compound, therefore, represents a promising therapeutic strategy.
Authors
- Xiaozhong Peng (ORCID: https://orcid.org/0000-0002-9592-9554)
- Shuaiyao Lu (ORCID: https://orcid.org/0000-0003-1675-9735)
- Yu Cheng (ORCID: https://orcid.org/0000-0002-9030-2023)
- Tingfu Du (ORCID: https://orcid.org/0000-0002-9814-0081)
- Junbin Wang
- Bin Yin
- Longying Shen
- Xintian Zhang
- Xiandao Pan
- Wenhai Yu
- Ruixue Liu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Institute of Laboratory Animal Science (CN)
Publication Details
- Journal
- MedComm
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/mco2.70715
- Primary Topic
- Chemical synthesis and alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.00