Gli1+ Cells Exhibit Clonogenicity and Slow-Cycling Features at the Temporomandibular Joint (TMJ) Enthesis–Condyle Interface
), and produced more confluent, rapidly expanding colonies. We hypothesize that these colonies are primarily composed of transit amplifying cells (TACs), which may proliferate robustly but face challenges in terminal differentiation. These results reveal critical roles for EVC2 and regional progenitor cell diversity in TMJ regenerative biology and suggest that targeting cell signaling and mechanical factors may inform novel strategies for TMJ disorder therapies.
Authors
- H Zhang
- Rafael Correia Cavalcante (ORCID: https://orcid.org/0000-0001-6466-5165)
- Yuji M. Mishina (ORCID: https://orcid.org/0000-0002-6268-4204)
- X. Peter (ORCID: https://orcid.org/0000-0002-0191-9487)
Institutions
- University of Michigan (US)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2026-04-07
- DOI
- https://doi.org/10.3390/ijms27073324
- Primary Topic
- Temporomandibular Joint Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Center for Research Resources