Development and validation of an activatable PET radiotracer reporting extracellular myeloperoxidase activity for the detection of unstable atherosclerotic plaque
Ga]Ga-IEMA is a promising translational candidate for the non-invasive identification of high-risk atherosclerotic plaques and the evaluation of therapies targeting arterial inflammation.
Authors
- James Nadel (ORCID: https://orcid.org/0000-0001-9259-2813)
- Sergey Tumanov (ORCID: https://orcid.org/0000-0002-0557-3153)
- George P. Keeling (ORCID: https://orcid.org/0000-0003-1501-3288)
- Weiyu Chen
- Roland Stocker
- Piotr GOLDA
- Lefteris Livieratos (ORCID: https://orcid.org/0009-0009-2156-8889)
- Marcelo E. Andía (ORCID: https://orcid.org/0000-0002-1251-5832)
- Prakash Saha (ORCID: https://orcid.org/0000-0002-9591-1063)
- Alkystis Phinikaridou
- Ling Gao (ORCID: https://orcid.org/0000-0003-0714-7200)
- Nadia Chaher
- Mohammed M. Chowdhury (ORCID: https://orcid.org/0000-0003-0384-7197)
- Xiaoying Wang
Institutions
- London Metropolitan University (GB)
- The University of Sydney (AU)
- Pontificia Universidad Católica de Chile (CL)
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- University of Cambridge (GB)
- The Heart Research Institute (AU)
- St Vincent's Hospital Sydney (AU)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- King's College School (GB)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- npj Imaging
- Published
- 2026-04-07
- DOI
- https://doi.org/10.1038/s44303-026-00156-9
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- British Heart Foundation
- Department of Health and Social Care
- King's College London
- Heart Research Institute
- European Association of Cardiovascular Imaging
- Engineering and Physical Sciences Research Council
- Centre For Medical Engineering, King’s College London