Magnetic Particle Imaging Distinguishes Viable and Damaged Cells by Exploiting Distinct Magnetic Signatures of Internalized Nanoparticles
trends over 72 h, which indicated that cell type and intracellular processing distinctly modulate the magnetic signatures. Exposure to extracellular oxidative stress induced a distinct magnetic signature of internalized SynC. Color MPI successfully visualized these magnetic signature differences between oxidatively damaged and viable cells within mixed populations. These findings demonstrated that cell physiological modulation of the magnetic signatures of internalized nanoparticles enables simultaneous mapping of cell location and physiology. This established a proof-of-principle for a magnetic nanoparticle-based approach that might enable monitoring of cell state during regenerative and immunotherapies.
Authors
- Anke Stach (ORCID: https://orcid.org/0009-0000-8218-0364)
- Norbert Löwa (ORCID: https://orcid.org/0000-0001-6245-9042)
- Frank Wiekhorst (ORCID: https://orcid.org/0000-0003-0608-1473)
- Lena Kampen (ORCID: https://orcid.org/0000-0002-2251-1886)
- Amani Remmo (ORCID: https://orcid.org/0000-0003-4171-5283)
- Olaf Kosch (ORCID: https://orcid.org/0000-0002-6740-8217)
- Antje Ludwig (ORCID: https://orcid.org/0000-0002-8369-7020)
- Nike D. C. Fiebig
Institutions
- Physikalisch-Technische Bundesanstalt (DE)
- Humboldt-Universität zu Berlin (DE)
- Deutsches Herzzentrum der Charité (DE)
- German Centre for Cardiovascular Research (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Small Science
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/smsc.202500601
- Primary Topic
- Characterization and Applications of Magnetic Nanoparticles
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Deutsche Forschungsgemeinschaft