Dementia Incidence in Individuals With Parkinson's Disease in the Framingham Heart Study
Limited information exists on incident dementia in individuals with Parkinson's disease (PD) in US community-based samples. We examined cognitive statuses and PD diagnoses of 183 individuals in the Framingham Heart Study (FHS) to establish incident dementia, mortality rates, associations with sex, age at PD onset, and education level. Annual incidence rates of dementia (5.0%, 95% CI [3.7%-6.4%]) and mortality (10.5%, 95% CI [8.7%-12.3%]), did not differ by sex or education level. Increased age at PD diagnosis was a significant risk factor for incident dementia and mortality. Sex may not be a significant risk factor for community-based PD dementia.
Authors
- Ludy C. Shih (ORCID: https://orcid.org/0000-0002-6590-8365)
- Joshi Dookhy (ORCID: https://orcid.org/0000-0001-7271-2021)
- Samuel Frank (ORCID: https://orcid.org/0000-0002-1866-162X)
- Eden Price
- Ting Fang Alvin Ang (ORCID: https://orcid.org/0000-0003-4687-2552)
- Ashita S. Gurnani
- Michael P. Cummings (ORCID: https://orcid.org/0000-0002-1467-0334)
- Sarah O'Shea
- Rhoda Au
- Jesse Mez
- Yulin Liu
- Santiago Gutierrez‐Gomez
Institutions
- University College Dublin (IE)
- Boston University (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- University Hospital Galway (IE)
- Framingham Heart Study (US)
- Columbia University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2026-04-07
- DOI
- https://doi.org/10.1002/acn3.70383
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Aging
- National Heart, Lung, and Blood Institute