Lysosomal dysfunction in diabetes and diabetic complications

Lysosomes, as organelles with degradative, secretory and signaling functions in eukaryotic cells, play a pivotal role in maintaining cellular energy homeostasis and biological recycling processes. In recent years, lysosomal dysfunction has garnered extensive attention from scholars for its implications in neurodegenerative and autoimmune diseases. however, its role in the occurrence and progression of diabetes mellitus and its complications remains to be further explored. Therefore, this article summarizes the research progress on lysosomal dysfunction in diabetes and its complications, hoping to highlight a promising therapeutic direction.