Fatty acid biosynthesis inhibitors fabimycin and triclosan trigger distinct resistance mutations in FabI and potently kill Gram-negative pathogens
evaluation of the prominent resistant mutants indicates poor fitness, with the most fit mutant still susceptible to fabimycin. Collectively, these results suggest the combination use of two antibiotics that engage different positions on the same target as a means to kill pathogenic bacteria and limit resistance.
Authors
- Andrei L. Osterman (ORCID: https://orcid.org/0000-0002-3810-9824)
- Marinela L. Elane (ORCID: https://orcid.org/0000-0002-8116-6058)
- James E. Kent (ORCID: https://orcid.org/0000-0002-4856-525X)
- Gee W. Lau (ORCID: https://orcid.org/0000-0002-7962-3950)
- Brett N. Cain
- Paul J Hergenrother
- Myung Rhul Lee
- John D Williams
Institutions
- University of Illinois Urbana-Champaign (US)
- Discovery Institute (US)
- Walter Reed Army Institute of Research (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-06
- DOI
- https://doi.org/10.64898/2026.04.05.716606
- Primary Topic
- Antimicrobial agents and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00