Post-COVID increase in N-methyl-2-pyridone-5-carboxamide (Met2PY) and N-methyl-4-pyridone-3-carboxamide (Met4PY) associates with inflammatory and endothelial activation markers
metabolism and accumulation of pyridone metabolites, particularly Met2PY, are associated with markers of chronic endothelial activation and inflammation in long COVID. These findings support the potential utility of Met2PY as a biomarker to identify patients at higher risk for endothelial dysfunction and cardiovascular events, enabling more personalized risk stratification and follow-up.
Authors
- Marcin Hellmann (ORCID: https://orcid.org/0000-0003-0403-805X)
- Agata Jędrzejewska (ORCID: https://orcid.org/0000-0002-8219-7497)
- Marta Żarczyńska-Buchowiecka (ORCID: https://orcid.org/0000-0002-2963-5419)
- Paulina Mierzejewska (ORCID: https://orcid.org/0000-0003-1363-7951)
- Dominika Sawicka
- Alicja Braczko (ORCID: https://orcid.org/0000-0002-4394-0292)
- Barbara Kutryb-Zając
- Aleksandra Jóźwiak
- Marzena Romanowska-Kocejko
- Małgorzata Zawrzykraj
- Milena Deptuła
- Michał Pikuła
Institutions
- Gdańsk Medical University (PL)
Publication Details
- Journal
- Nucleosides Nucleotides & Nucleic Acids
- Published
- 2026-04-07
- DOI
- https://doi.org/10.1080/15257770.2026.2650677
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00