Synthesis of Carbon‐13 and Carbon‐14 Labeled BI 690517 (Vicadrostat) and Its <i>O</i> ‐Glucuronide Metabolite BI 689875

C]-1 was obtained with a specific activity of 55.6 mCi/mmol (2.05 GBq/mmol), chemical and radiochemical purities higher than 98%, and with enantiomeric excess higher than 99%. Vicadrostat undergoes extensive hepatic glucuronidation to form the O-glucuronide BI 689875 (2). Both carbon-13 and carbon-14 labeled BI 689875 were also synthesized.

Authors

Maxim V. Chevliakov
Lalith P. Samankumara
Nizar Haddad (ORCID: https://orcid.org/0000-0001-7068-7897)
Matt Hrapchak
Bachir Latli (ORCID: https://orcid.org/0000-0002-0024-9792)
Saad Khattabi

Institutions

Boehringer Ingelheim (Brazil) (BR)
Boehringer Ingelheim (Japan) (JP)

Publication Details

Journal: Journal of Labelled Compounds and Radiopharmaceuticals
Published: 2026-04-01
DOI: https://doi.org/10.1002/jlcr.70026
Primary Topic: Hormonal Regulation and Hypertension
Type: article
Field-Weighted Citation Impact: 0.00

Controls

|||

ALL TIME

JAN

FEB

MAR

APR

MAY

JUN

JUL

AUG

SEP

OCT

article

Synthesis of Carbon‐13 and Carbon‐14 Labeled BI 690517 (Vicadrostat) and Its O ‐Glucuronide Metabolite BI 689875

Maxim V. Chevliakov, Lalith P. Samankumara, Nizar Haddad, Matt Hrapchak et al.

Apr 1, 2026

Journal of Labelled Compounds and Radiopharmaceuticals

Hormonal Regulation and Hypertension

article

Synthesis of Carbon‐13 and Carbon‐14 Labeled BI 690517 (Vicadrostat) and Its O ‐Glucuronide Metabolite BI 689875

Maxim V. Chevliakov, Lalith P. Samankumara, Nizar Haddad, Matt Hrapchak, Bachir Latli, Saad Khattabi

April 1, 2026article en

Abstract

C]-1 was obtained with a specific activity of 55.6 mCi/mmol (2.05 GBq/mmol), chemical and radiochemical purities higher than 98%, and with enantiomeric excess higher than 99%. Vicadrostat undergoes extensive hepatic glucuronidation to form the O-glucuronide BI 689875 (2). Both carbon-13 and carbon-14 labeled BI 689875 were also synthesized.

Journal of Labelled Compounds and RadiopharmaceuticalsVol. 69(4-6)

Boehringer Ingelheim (Brazil) (BR), Boehringer Ingelheim (Japan) (JP)

Openalex Percentile: Top 24%

Hormonal Regulation and Hypertension

DOI Source OpenAlex

AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.