Limitations of Raised Thyroglobulin: Two Cases of Benign Lymphadenopathy Mimicking Thyroid Carcinoma

Markedly elevated thyroglobulin (Tg) washout is often considered highly suggestive of metastatic differentiated thyroid cancer. We present two cases of false-positive Tg washout in cervical lymph nodes with benign pathology, notably in patients who were carriers of iron-handling disorders. These findings highlight the limitations of Tg washout as a standalone marker and the need for multimodal interpretation.

Authors

Institutions

Publication Details

Journal
The Laryngoscope
Published
2026-04-06
DOI
https://doi.org/10.1002/lary.70556
Primary Topic
Thyroid Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Limitations of Raised Thyroglobulin: Two Cases of Benign Lymphadenopathy Mimicking Thyroid Carcinoma

Isaac Wasserman, Jeremy D. Richmon, Justine Philteos, Shireen S. Gohari
The Laryngoscope
Thyroid Cancer Diagnosis and Treatment
article

Limitations of Raised Thyroglobulin: Two Cases of Benign Lymphadenopathy Mimicking Thyroid Carcinoma

Isaac Wasserman, Jeremy D. Richmon, Justine Philteos, Shireen S. Gohari
article en

Abstract

Markedly elevated thyroglobulin (Tg) washout is often considered highly suggestive of metastatic differentiated thyroid cancer. We present two cases of false-positive Tg washout in cervical lymph nodes with benign pathology, notably in patients who were carriers of iron-handling disorders. These findings highlight the limitations of Tg washout as a standalone marker and the need for multimodal interpretation.

The Laryngoscope
Massachusetts Eye and Ear Infirmary (US), Harvard University (US)
Good health and well-being
Openalex Percentile: Top 22%
Thyroid Cancer Diagnosis and Treatment
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.