Limitations of Raised Thyroglobulin: Two Cases of Benign Lymphadenopathy Mimicking Thyroid Carcinoma
Markedly elevated thyroglobulin (Tg) washout is often considered highly suggestive of metastatic differentiated thyroid cancer. We present two cases of false-positive Tg washout in cervical lymph nodes with benign pathology, notably in patients who were carriers of iron-handling disorders. These findings highlight the limitations of Tg washout as a standalone marker and the need for multimodal interpretation.
Authors
- Isaac Wasserman (ORCID: https://orcid.org/0000-0002-6955-0567)
- Jeremy D. Richmon (ORCID: https://orcid.org/0000-0002-6588-6549)
- Justine Philteos (ORCID: https://orcid.org/0000-0002-3526-1345)
- Shireen S. Gohari
Institutions
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
Publication Details
- Journal
- The Laryngoscope
- Published
- 2026-04-06
- DOI
- https://doi.org/10.1002/lary.70556
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00