Antiproliferative Effect of 24‐Deoxysericoside From <scp> <i>Terminalia macroptera</i> </scp> Guill. & Perr. (Combretaceae) Against Breast Carcinoma: In Vitro, Molecular Docking and <scp>ADME</scp> Assessment
BACKGROUND: Terminalia macroptera (Combretaceae) is an important medicinal plant in the traditional pharmacopeia in most tropical areas, where its different parts are used in treating illnesses including cancer. AIMS: In this study, two oleanane-type triterpenoids: terminolic acid (TM32) and arjungenin (TM34), together with three saponins: arjunglucoside I (TM35), 24-deoxysericoside (TM36) and chebuloside II (TM37) from T. macroptera, were screened for their cytotoxic effects against breast cancer cell lines. METHODS AND RESULTS: (PI3Kα receptor). The compounds exhibited appreciable drug likeness predicted using SwissADME. CONCLUSION: The studies showed that the isolated compounds could be used for the development of anticancer therapies.
Authors
- Roméo Toko Feunaing (ORCID: https://orcid.org/0009-0003-8690-9660)
- El Hassane Anouar (ORCID: https://orcid.org/0000-0001-9240-7163)
- Alfred Ngenge Tamfu (ORCID: https://orcid.org/0000-0001-6683-3337)
- Stéphane Zingue (ORCID: https://orcid.org/0000-0002-4854-8783)
- Cyrille Leonel Tchuente Djoko
- Abel Joël Yaya Gbaweng
- Emmanuel Talla
Institutions
- Université de Yaoundé I (CM)
- Prince Sattam Bin Abdulaziz University (SA)
- University of Ngaoundéré (CM)
Publication Details
- Journal
- Cancer Reports
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/cnr2.70541
- Primary Topic
- Phytochemicals and Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Prince Sattam bin Abdulaziz University
- Organisation for the Prohibition of Chemical Weapons