A Histone Deacetylase Activity Model for the Discovery and Validation of Sepsis Biomarkers

INTRODUCTION: Histone deacetylases (HDACs) play critical roles in immune regulation and inflammatory responses in sepsis. This study identified HDAC-related genes and explored their potential roles in sepsis. MATERIALS AND METHODS: knockdown on cell apoptosis and inflammatory responses was analyzed. RESULTS: knockdown markedly lowered the levels of pro-inflammatory cytokines and apoptosis. DISCUSSION: The two biomarkers, along with the RiskScore model, could potentially contribute to the prognostic assessment of sepsis and the development of personalized treatment. However, further experimental validation is also needed to substantiate our findings and to translate them into practical clinical applications. CONCLUSION: as key HDAC-related biomarkers for sepsis, providing novel insights for the early diagnosis and targeted treatments of sepsis.