Polymer‐Based Prism‐Free Nanograting SPR Imaging Enables Multiplexed Detection and Single‐Step Aptamer Binding Kinetics (Small 20/2026)
Surface Plasmon Resonance Imaging In the Research Article (e12092), Chia-Fu Chou and co-workers present a prism-free, low-cost, single-use polymer-based nanograting surface plasmon resonance imaging (SPRi) platform using normal-incidence optics and camera-based detection. Integrated with a custom microarrayer, the platform demonstrates multiplexed analysis capability. Furthermore, the incorporation of microfluidics enables simultaneous, multi-concentration kinetic analysis in a single step. This approach offers high-throughput potential for biomedical applications.
Authors
- K.G. Lee
- Pierre-François Calmon
- Chia‐Fu Chou (ORCID: https://orcid.org/0000-0003-0070-5556)
- Thierry Leïchlé (ORCID: https://orcid.org/0000-0003-3183-8976)
- Pei‐Kuen Wei (ORCID: https://orcid.org/0000-0002-3002-0526)
- Shu-Cheng Lo
- Tzu‐Tsai Chu
- Liang‐Kun Yu
- Yi‐De He
- Deng‐Kai Yang
- Jui‐Hong Weng
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Laboratoire d'Analyse et d'Architecture des Systèmes (FR)
- National Chi Nan University (TW)
- Atlanta Technical College (US)
- Georgia Tech-CNRS Laboratory (FR)
- Research Center for Applied Science, Academia Sinica (TW)
- Institute of Physics, Academia Sinica (TW)
- ICF International (United States) (US)
Publication Details
- Journal
- Small
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/smll.73072
- Primary Topic
- Advanced Biosensing Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00