Cisplatin Promotes Immunosuppression in Ovarian Cancer by Enhancing miR‐181a‐5p‐Enriched Extracellular Vesicles to Drive Regulatory T Cell Differentiation
differentiation but also restored T-cell-mediated antitumour immunity and restrained tumour growth. Together, these findings uncover a previously unrecognised mechanism by which CDDP exacerbates immunosuppression via miR-181a-5p-enriched EVs and suggest that targeting this pathway could improve the therapeutic efficacy of combination immunotherapy in ovarian cancer.
Authors
- Fengli Qu (ORCID: https://orcid.org/0009-0003-2248-8609)
- Yuting Dai
- Mei Liu (ORCID: https://orcid.org/0000-0003-0445-941X)
- Sijia Mu
- Panmin Lei
- Jingchen Zhang
- Weihong Tan
- Chenxi He
Institutions
- Tianjin University (CN)
- Hunan University (CN)
- Qufu Normal University (CN)
- Zhejiang Cancer Hospital (CN)
Publication Details
- Journal
- Journal of Extracellular Vesicles
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/jev2.70261
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- University of Chinese Academy of Sciences