Glypican‐3 Upregulated by <scp>YTHDF1</scp> in an <scp>m6A</scp> ‐Dependent Manner Interacts With <scp>MUL1</scp> to Repress <scp>HSF1</scp> Ubiquitination Degradation, Boost <scp>CD276</scp> Transcription, and Mediate Immune Escape in Gastric Cancer
T cells through the MUL1/HSF1/CD276 axis, mediating GC tumor immune escape. YTHDF1 upregulates the expression of GPC3 in GC in an m6A-dependent manner. GPC3 interacts with MUL1 to depress the ubiquitination degradation of HSF1, thereby upregulating the immune checkpoint CD276 and affecting GC immune escape.
Authors
- Dinuo Li (ORCID: https://orcid.org/0000-0001-7317-5045)
- Chen Li
Institutions
- Affiliated Hospital of Jining Medical University (CN)
- Jinzhou Medical University (CN)
Publication Details
- Journal
- The FASEB Journal
- Published
- 2026-04-07
- DOI
- https://doi.org/10.1096/fj.202503106r
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00