Immunohistochemical Expression of IDO and PD-L1 in Distinct Compartments of Breast Cancer Tissue: Correlation with Clinicopathological Features and Outcomes
: In our study, IDO expression on tumor cells was predominantly observed in TNBC and was found to correlate with PD-L1 expression in the lymphocytic and stromal compartments. Furthermore, expression of PD-L1 among lymphocytes was found to independently correlate with unfavorable clinicopathological parameters, including high proliferation rate and negative hormone receptor status.
Authors
- Nikolaos Syrigos
- Ηλίας Κοττέας (ORCID: https://orcid.org/0000-0003-2563-0968)
- Anastasia Karachaliou (ORCID: https://orcid.org/0000-0001-9506-5090)
- Anastasia Konstantinidou (ORCID: https://orcid.org/0000-0002-2458-988X)
- C. MarKopoulos
- Ioannis Vamvakaris (ORCID: https://orcid.org/0000-0002-2917-7155)
- Dimitra Grapsa
- E. Panagiotou
- Theodoros Troupis
- Sophocles Lanitis
- Evangelia Karagianni
- Eleni Fyta
- Alexandros Mougiakos
Institutions
- National and Kapodistrian University of Athens (GR)
- Academy of Athens (GR)
- Sotiria General Hospital (GR)
Publication Details
- Journal
- Cancers
- Published
- 2026-04-07
- DOI
- https://doi.org/10.3390/cancers18071180
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00