Influence of <i>MTHFD1L</i> variants on the susceptibility to hypertension in the Chinese Han population

BACKGROUND: gene variations and hypertension risk is limited. METHODS: SNP interactions on hypertension risk. RESULTS: , OR = 0.59) were associated with hypertension risk. Interestingly, rs6922269 was more significantly related to an increased hypertension risk in females, whereas rs1555179 was more significantly associated with a reduced risk in males. Moreover, rs803419 might contribute to a reduced susceptibility to hypertension in females. Notably, rs1555179 was the most informative single-locus model for hypertension risk with an information gain (IG) of 2.44%. CONCLUSION: gene in hypertension occurrence.