Programmable Dual‐Targeting Nano Bioconjugates: a Universal Bioconjugation Strategy to Enhance Single Molecule Proteomic Assays (Small Methods 7/2026)
Front Cover The image illustrates programmable dual-targeting nano-bioconjugates formed by assembling bispecific antibody fragments (BsAbs) on PEGylated nanoparticle clusters. BsAbs enable precise dual recognition at the single-molecule level, demonstrating the specificity and modularity of this strategy. Controlled BsAb-F conjugation on mPEG nanoparticles improves SERS-based biosensing for ultrasensitive, multiplexed biomarker detection and supports broader applications in functional nanomaterial design. More in article number e01235, Alain Wuethrich, Christopher B. Howard, Matt Trau, and co-workers.
Authors
- Will Anderson
- Alain Wuethrich (ORCID: https://orcid.org/0000-0001-9569-0478)
- Fahimeh Farokhinejad (ORCID: https://orcid.org/0000-0002-6076-7903)
- Christopher B. Howard (ORCID: https://orcid.org/0000-0001-9797-8686)
- Matt Trau (ORCID: https://orcid.org/0000-0001-5516-1280)
- Xueming Niu (ORCID: https://orcid.org/0000-0003-3597-6786)
Institutions
- The University of Queensland (AU)
- Australian National Fabrication Facility (AU)
Publication Details
- Journal
- Small Methods
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/smtd.70581
- Primary Topic
- Advanced Biosensing Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00