Modulating IDO1 and TDO Inhibition Through Structural Modification of Diaryl Hydroxylamines
= 0.18/5.5 μM) displayed the most favorable activity profiles. This SAR study defines key determinants of IDO1 potency while retaining significant TDO inhibition and identifies fluorinated hydroxylamines as potential starting points for future PET imaging probe development.
Authors
- Anastasia Mpakali (ORCID: https://orcid.org/0000-0003-0869-9680)
- Aristeidis Chiotellis (ORCID: https://orcid.org/0000-0003-0052-8393)
- Minas S. Papadopoulos (ORCID: https://orcid.org/0000-0002-1107-027X)
- Angeliki‐Sofia Foscolos (ORCID: https://orcid.org/0000-0001-8123-5060)
- Grigoris Zoidis (ORCID: https://orcid.org/0000-0002-9442-5186)
- Alexandros Pappas
- Anna Kapella
- Christos N. Petroulias
- Georgia M. Prifti
Institutions
- National and Kapodistrian University of Athens (GR)
- National Centre of Scientific Research "Demokritos" (GR)
Publication Details
- Journal
- ChemMedChem
- Published
- 2026-04-07
- DOI
- https://doi.org/10.1002/cmdc.202501087
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gilead Sciences
- Hellenic Academic Libraries Link
- European Social Fund