<scp>STAT4</scp> ‐dependent regulation of neuroinflammation in atherosclerosis
mice and increases the number of efferocytotic macrophages. Accordingly, STAT4 deficiency also reduces neuronal death. Overall, our data reveal an important role for myeloid-driven STAT4 expression in the pathogenesis of cognitive decline associated with atherosclerosis, mediated through impaired efferocytosis and enhanced leukocyte activation, leading to increased brain neuroinflammation.
Authors
- Elena Galkina (ORCID: https://orcid.org/0000-0002-0001-685X)
- Alina Moriarty (ORCID: https://orcid.org/0009-0002-6402-4661)
- Larry D. Sanford (ORCID: https://orcid.org/0000-0001-8425-8778)
- Natalie Stahr (ORCID: https://orcid.org/0000-0002-7611-8780)
- W. Coles Keeter
- Shelby D. Ma
- Woong‐Ki Kim
Institutions
- Tulane University (US)
- Eastern Virginia Medical School (US)
- Old Dominion University (US)
Publication Details
- Journal
- Physiological Reports
- Published
- 2026-04-01
- DOI
- https://doi.org/10.14814/phy2.70856
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Heart Association
- Eastern Virginia Medical School
- National Institutes of Health
- National Heart, Lung, and Blood Institute