Effect of intravenous immunoglobulin combined with azithromycin sequential therapy on clinical outcomes and immune response in children with Mycoplasma pneumoniae pneumonia: a retrospective study

Background: pneumonia (MPP) is a common pediatric respiratory infection that can lead to serious complications. Increasing macrolide resistance and limited efficacy of antibiotic monotherapy necessitate exploration of adjunctive treatment strategies. Methods: = 70). Baseline characteristics were comparable between groups; however, disease severity was not formally stratified. Outcomes included clinical efficacy, time to symptom resolution, inflammatory cytokines (IL-6, TNF, IL-2), immunoglobulin levels (IgG, IgA, IgM), pulmonary function, and adverse events. Multivariable logistic regression was used to adjust for baseline covariates. Results: > 0.05). Conclusion: Adjunctive IVIG combined with azithromycin was associated with improved clinical and laboratory outcomes in children with MPP without increasing adverse events. Findings should be interpreted cautiously due to the retrospective design and potential residual confounding.