Dual antibacterial action of ethyl ferulate as antibiofilm molecule and antibiotic synergist against Escherichia coli
Introduction: enhances its pathogenicity and antibiotic resistance, posing a serious threat to human and animal health. Methods: using crystal violet (CV) staining and Alamar Blue (AB) assay. The expression levels of biofilm-related genes were analyzed by qRT-PCR. Results: ). Notably, EF exhibited significant antimicrobial synergistic effects when combined with commercially available antibiotics (fosfomycin sodium, cefquinome, gentamicin, tetracycline, and azithromycin), markedly enhancing their antibacterial efficacy. Discussion: infections.
Authors
- Xiaojuan Wei
- Zhen Zhu (ORCID: https://orcid.org/0000-0003-0530-1526)
- Weiwei Wang (ORCID: https://orcid.org/0000-0002-5398-6809)
- Bo Li (ORCID: https://orcid.org/0000-0003-0035-221X)
- Jing Zhang (ORCID: https://orcid.org/0000-0003-3064-7625)
- Jiayi Xu (ORCID: https://orcid.org/0000-0003-3465-7927)
- Zhijin Zhang (ORCID: https://orcid.org/0000-0002-9579-2615)
- Yubin Bai
- Zixuan Shang
- Rongbin Hu
Institutions
- Hebei University of Engineering (CN)
- Lanzhou Institute of Husbandry and Pharmaceutical Sciences (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-04-07
- DOI
- https://doi.org/10.3389/fcimb.2026.1789180
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 0.00