Diagnosis of Ductal Carcinoma in Situ in Breast Biopsies for a Radiological Mass Lesion: Did We Miss Something?

= .0451). Specific DCIS morphological subtypes-including encapsulated papillary carcinoma, solid papillary carcinoma, papillary DCIS, and cystic apocrine DCIS-were identified as plausible causes of mass-forming lesions. No statistically significant histologic predictors of invasive carcinoma on excision were identified in our limited study cohort.ConclusionsDCIS with associated desmoplastic stromal fibrosis, along with some specific histologic subtypes, can cause mass-forming lesions on imaging. Histologic features alone are not reliable predictors of coexisting invasive carcinoma. Careful pathologic-radiologic correlation, including attention to benign mass-forming correlates, is essential for accurate diagnosis and clinical management.