LDL-C modifies the association between triglycerides and depression identified by threshold scanning in US adults

= 0.002). Sensitivity analyses incorporating eight distinct analytical conditions consistently confirmed LDL-C = 3.6 mmol/L as a significant effect modifier of the TG-depression association. TG showed a significant positive association with depression in the context of high LDL-C, with 3.6 mmol/L emerging as an optimal threshold for identifying this interaction effect. This finding underscores the importance of considering lipid-lipid interactions when evaluating the link between lipid profiles and depression.