Bilateral Lower Limb Sensory Motor Neuropathy as the Initial Manifestation of Borderline Tuberculoid Leprosy: A Diagnostic Challenge

ABSTRACT: Leprosy primarily affects the skin and peripheral nerves, with neuropathy usually accompanying skin lesions. Rarely, neural involvement may precede cutaneous manifestations, leading to diagnostic delay. We report the case of a 36-year-old male presenting with bilateral lower limb sensory motor neuropathy initially attributed to Vitamin B12 deficiency. Despite normalization of B12 levels, symptoms persisted, and subsequent skin changes led to biopsy confirmation of borderline tuberculoid leprosy. This case emphasizes considering Hansen's disease in patients with unexplained neuropathy, particularly in the endemic regions, even before overt skin lesions appear.

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Publication Details

Journal
Annals of African Medicine
Published
2026-04-07
DOI
https://doi.org/10.4103/aam.aam_74_26
Primary Topic
Leprosy Research and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Bilateral Lower Limb Sensory Motor Neuropathy as the Initial Manifestation of Borderline Tuberculoid Leprosy: A Diagnostic Challenge

B. Varun Kumar, Mohini Singh
Annals of African Medicine
Leprosy Research and Treatment
article

Bilateral Lower Limb Sensory Motor Neuropathy as the Initial Manifestation of Borderline Tuberculoid Leprosy: A Diagnostic Challenge

B. Varun Kumar, Mohini Singh
article en

Abstract

ABSTRACT: Leprosy primarily affects the skin and peripheral nerves, with neuropathy usually accompanying skin lesions. Rarely, neural involvement may precede cutaneous manifestations, leading to diagnostic delay. We report the case of a 36-year-old male presenting with bilateral lower limb sensory motor neuropathy initially attributed to Vitamin B12 deficiency. Despite normalization of B12 levels, symptoms persisted, and subsequent skin changes led to biopsy confirmation of borderline tuberculoid leprosy. This case emphasizes considering Hansen's disease in patients with unexplained neuropathy, particularly in the endemic regions, even before overt skin lesions appear.

Annals of African Medicine
Sri Ramachandra Institute of Higher Education and Research (IN)
Good health and well-being
Openalex Percentile: Top 20%
Leprosy Research and Treatment
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