Exosome-Mitochondrial Hybrid Membrane with Targeted Delivery of CO Prevents Mitochondrial Dysfunction and Pyroptosis against Myocardial Ischemia-Reperfusion Injury
. Moreover, a single intravenous injection of EM@CO attenuates inflammatory amplification in cardiac tissue by promoting M1 to M2 macrophage polarization. It can effectively decrease the pro-inflammatory cytokine release and inhibit inflammation, thereby attenuating myocardial infarction and improving cardiac function. In summary, the findings of this study reveal the potential for restoring mitochondrial function through targeted gas therapy to eliminate reactive oxygen species (ROS) and inhibit cellular pyroptosis, which holds promise for ameliorating myocardial ischemia-reperfusion injury.
Authors
- Dujuan Sha (ORCID: https://orcid.org/0000-0002-2461-1725)
- Xi Chen (ORCID: https://orcid.org/0000-0002-8523-3967)
- Jian Sun (ORCID: https://orcid.org/0000-0003-0067-5967)
- Hao Ren (ORCID: https://orcid.org/0000-0003-4182-8886)
- Qijun Fang
- Lina Kang
- J. Ni
- Lintao Wang
- Mengyao Xu
- Qianzhi Shi
- Xudong Wang
- Xinyu Wang
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Tech University (CN)
- Nanjing Drum Tower Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- ACS Nano
- Published
- 2026-04-07
- DOI
- https://doi.org/10.1021/acsnano.5c21479
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Medical Science and Technology Development Foundation, Nanjing Municipality Health Bureau