Discovery of the First Brain-Penetrant Radioligands for Visualizing the GABA Transporter 1 (GAT-1): Synthesis, <i>In Vitro</i> Screening, and <i>In Vivo</i> Evaluation in Nonhuman Primates

Authors

G. Tamagnan
Nabeel Nabulsi (ORCID: https://orcid.org/0000-0001-8129-0051)
Luca B. Gobbi (ORCID: https://orcid.org/0000-0002-0563-2491)
Jim Ropchan (ORCID: https://orcid.org/0000-0002-1105-7489)
Paul Gravel (ORCID: https://orcid.org/0000-0003-3702-7314)
Lei Zhang (ORCID: https://orcid.org/0000-0001-5311-6830)
Edilio Borroni (ORCID: https://orcid.org/0000-0001-9689-7374)
Michael Honer
M. Zheng
Chao Wang
Hong Gao
Jiwei Gu
Richard Carson

Institutions

Roche (Switzerland) (CH)
Yale University (US)
Laboratoire d’Imagerie Biomédicale (FR)
Imaging Center (US)

Publication Details

Journal: Journal of Medicinal Chemistry
Published: 2026-04-07
DOI: https://doi.org/10.1021/acs.jmedchem.5c03014
Primary Topic: Neuroscience and Neuropharmacology Research
Type: article
Field-Weighted Citation Impact: 0.00

Funders

National Institutes of Health

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article

Discovery of the First Brain-Penetrant Radioligands for Visualizing the GABA Transporter 1 (GAT-1): Synthesis, In Vitro Screening, and In Vivo Evaluation in Nonhuman Primates

G. Tamagnan, Nabeel Nabulsi, Luca B. Gobbi, Jim Ropchan et al.

Apr 7, 2026

Journal of Medicinal Chemistry

Neuroscience and Neuropharmacology Research

article

Discovery of the First Brain-Penetrant Radioligands for Visualizing the GABA Transporter 1 (GAT-1): Synthesis, In Vitro Screening, and In Vivo Evaluation in Nonhuman Primates

G. Tamagnan, Nabeel Nabulsi, Luca B. Gobbi, Jim Ropchan, Paul Gravel, Lei Zhang, Edilio Borroni, Michael Honer, M. Zheng, Chao Wang, Hong Gao, Jiwei Gu, Richard Carson

April 7, 2026article en

Abstract

No abstract available for this paper.

Journal of Medicinal ChemistryVol. 69(8)

Roche (Switzerland) (CH), Yale University (US), Laboratoire d’Imagerie Biomédicale (FR), Imaging Center (US)

National Institutes of Health

Openalex Percentile: Top 25%

Neuroscience and Neuropharmacology Research

DOI Source OpenAlex

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