Blood Coagulation in COVID-19: Systems-Biology Evidence, Clinical Implications, and Therapeutic Opportunities in an Evolving Pandemic

Our integrative informatics analysis computationally prioritized coagulation-related pathways as prominent severity-associated host-response signatures in COVID-19. These systems-level findings position coagulation as a transcriptomically supported, central disease program rather than solely a secondary complication. The prioritization of VWF and additional host targets provides a data-driven framework for repositioning therapeutics against the coagulopathic sequelae of SARS-CoV-2 infection.