Enterohemorrhagic Escherichia coli senses colonic oxygen availability to modulate its virulence and colonization
, reflecting evolutionary adaptation. Additionally, ArcA suppresses Shiga toxin production. Our work reveals the ArcAB two-component system as a pivotal oxygen-sensing pathway that directly orchestrates locus of enterocyte effacement (LEE) gene expression and positions it as a promising target for antivirulence or metabolic interference strategies.
Authors
- Yunxin Xue (ORCID: https://orcid.org/0000-0002-6127-6049)
- Yunhe Li (ORCID: https://orcid.org/0000-0003-0780-3327)
- Liangding Dou
- Tanliang Ouyang (ORCID: https://orcid.org/0000-0001-6957-983X)
- Jinping Han
- Xuefang Xu
- Ying Zhong
- Dai Wang
- Fang Fang
Institutions
- Xiamen University (CN)
- National Institute for Communicable Disease Control and Prevention (CN)
- Children’s Hospital of Fudan University Xiamen Branch (CN)
- Xiamen Maternal and Child Health Hospital (CN)
- Putian University (CN)
Publication Details
- Journal
- iScience
- Published
- 2026-04-07
- DOI
- https://doi.org/10.1016/j.isci.2026.115632
- Primary Topic
- Escherichia coli research studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Putian University
- Science, Technology and Innovation Commission of Shenzhen Municipality