Elucidation of the aragonite nanofiber formation mechanism of LICP contained in the hinge ligament of <i>Pinctada fucata</i>
-axis, consistent with its selective surface binding. These findings demonstrated that conformational plasticity in short, disordered peptides enabled specific recognition of crystal faces and directed modulation of mineral growth. LICP serves as a minimal yet powerful model for exploring protein-mineral interfaces, offering broader insights into the structural principles by which intrinsically disordered peptides function in solid-phase biological systems.
Authors
- Fabio Nudelman (ORCID: https://orcid.org/0000-0001-7464-4309)
- Akira Shida
- Yutaka Ito (ORCID: https://orcid.org/0000-0002-1030-4660)
- Yuto Namikawa (ORCID: https://orcid.org/0000-0003-4312-636X)
- Taiga Okumura (ORCID: https://orcid.org/0000-0001-5252-8622)
- Hidekazu Katayama (ORCID: https://orcid.org/0000-0003-3367-9147)
- Taichi Morioka
- Teppei Ikeya (ORCID: https://orcid.org/0000-0002-6721-3727)
- Toshihiro Kogure (ORCID: https://orcid.org/0000-0002-3494-8989)
- Kei Futagawa (ORCID: https://orcid.org/0009-0004-4981-6657)
- Kazuo Furihata (ORCID: https://orcid.org/0000-0001-5811-5917)
- Haruki Meguro
- Koji Nagata
- Yuki Nagano
- Michio Suzuki
Institutions
- Planetary Science Institute (US)
- Waseda University (JP)
- Tokyo University of Science (JP)
- Tokyo Metropolitan University (JP)
- The University of Tokyo (JP)
- Teikyo University (JP)
- University of Edinburgh (GB)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-07
- DOI
- https://doi.org/10.1073/pnas.2522686123
- Primary Topic
- Calcium Carbonate Crystallization and Inhibition
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Environmental Restoration and Conservation Agency
- New Energy and Industrial Technology Development Organization
- Core Research for Evolutional Science and Technology